5/8/2023 0 Comments Sequencher mtdna![]() ![]() Received: ApAccepted: NovemPublished: December 7, 2015Ĭopyright: © 2015 De Fanti et al. PLoS ONE 10(12):Įditor: Ron Pinhasi, University College Dublin, IRELAND (2015) Fine Dissection of Human Mitochondrial DNA Haplogroup HV Lineages Reveals Paleolithic Signatures from European Glacial Refugia. The resulting hypothesis of a glacial refugium in Southern Italy has implications for the understanding of late Paleolithic population movements and is discussed within the archaeological cultural shifts occurred over the entire continent.Ĭitation: De Fanti S, Barbieri C, Sarno S, Sevini F, Vianello D, Tamm E, et al. We finally observe that Italy harbors a reservoir of mtDNA diversity, with deep-rooting HV lineages often related to sequences present in the Caucasus and the Middle East. We also confirm a major lineage expansion that probably followed the Late Glacial Maximum and preceded Neolithic population movements. We highlight points of instability in the particular topology of this haplogroup, reconstructed with BEAST-generated trees and networks. In this study, we present a revised HV topology based on full mtDNA genome data, and we include a comprehensive dataset consisting of 316 complete mtDNA sequences including 60 new samples from the Italian peninsula, a previously underrepresented geographic area. ![]() Up till now, variation within haplogroup HV was addressed mainly by analyzing sequence data from the mtDNA control region, except for specific sub-branches, such as HV4 or the widely distributed haplogroups H and V. Previous studies already suggested a pre-Neolithic diffusion of mitochondrial haplogroup HV*(xH,V) lineages, a relatively rare class of mtDNA types that includes parallel branches mainly distributed across Europe and West Asia with a certain degree of structure. Sequencing specifically targeted for mtDNA is commonly used in the diagnostic settings and has lower costs.Genetic signatures from the Paleolithic inhabitants of Eurasia can be traced from the early divergent mitochondrial DNA lineages still present in contemporary human populations. Whole genome sequencing is also costly and time consuming. Whole genome sequencing (WGS) has been the dominant sequencing approach to identify genetic variants in recent decades, but most studies focus on variants on the nuclear genome. While most researchers tend to overlook it because of its small size, the mitochondrial genome contains genes that are essential for cellular energetics and survival. The mitochondrial genome is an independent genetic system in each eukaryotic cell outside the nuclear genome. Mitochondrial DNA is only a small portion of the DNA in a eukaryotic cell most of the DNA can be found in the cell nucleus and, in plants and algae, also in plastids such as chloroplasts. Mitochondrial DNA (mtDNA or mDNA) is the DNA located in mitochondria, cellular organelles within eukaryotic cells that convert chemical energy from food into a form that cells can use, adenosine triphosphate (ATP). A new method for sequencing the mitochondrial genome by using long read technology ![]()
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